Turnstile across 2 famous tones — mostly through Peavey 5150 / EVH 5150 III blended with a Mesa Dual Rectifier, Orange Rockerverb / Mesa Dual Rectifier + 5150 blend — Gibson Les Paul, with active humbuckers. Here is where to start, then adapt any of it to the guitar and amp you actually own.
Starting point (averaged): gain 6.5 · bass 5 · mid 6 · treble 6.5 · presence 6 (out of 10)