The Black Keys across 3 famous tones — mostly through Marshall JTM-45 + Fender Quad Reverb + Victoria Dual Deluxe, with single-coils. Here is where to start, then adapt any of it to the guitar and amp you actually own.
Starting point (averaged): gain 5.5 · bass 5.5 · mid 6 · treble 6 · presence 5.5 (out of 10)