Soundgarden across 3 famous tones — mostly through Mesa/Boogie Trem-o-Verb + Electra Dyne, with humbuckers. Here is where to start, then adapt any of it to the guitar and amp you actually own.
Starting point (averaged): gain 6 · bass 6 · mid 6 · treble 6 · presence 5.5 (out of 10)