Bring Me the Horizon across 2 famous tones — mostly through Marshall JCM800, Two modded Marshall JCM800s into 1960A 4x12s — low-tuned Les Paul, with humbuckers. Here is where to start, then adapt any of it to the guitar and amp you actually own.
Starting point (averaged): gain 7 · bass 5 · mid 6.5 · treble 6.5 · presence 6 (out of 10)